The investigators hope to add to the volume of literature regarding the use of BMSC in those neurologic diseases and conditions identified as likely to respond to this treatment.
Intravenous administration of BMSC is a well-established approach to neurologic disease and injury with much support for its effectiveness in the pre-clinical and clinical literature. BMSC and the associated bone marrow fraction are posited to have a number of different mechanisms by which they may potentially improve neurologic function. In regards their ability to penetrate the blood-brain barrier for potential neuronal transdifferentiation and direct impact on the neurons and glial tissue within the brain, it should be remembered that within the diencephalon there are specific circumventricular organs which lie in the wall of the third ventricle.
These are noteworthy for a significantly diminished blood-brain barrier and glial limitans which facilitates their function of coordinating homeostatic mechanisms of the endocrine and nervous systems. Therefore the investigators believe entry of BMSC may be facilitated in this area of the brain. This is applied bilaterally to the inferior nasal conchas and meatuses.
The Trigeminal Nerve or 5th Cranial Nerve is a paired, large sensory and motor nerve with multiple branches. It provides sensation to the surface and interior structures of the face including the nasal mucosa that lines the nose. The nerves of the Trigeminal Nerve providing sensation to this area converge and enter the brain at the level of the pons. None Open Label Primary Purpose: June Estimated Primary Completion Date: June Estimated Study Completion Date: As examples, neurologic functions may include speech, balance, hearing, gait, strength, pain, parasthesias, etc.
Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. Ages Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria:. Hide glossary Glossary Study record managers: Search for terms x. Warning You have reached the maximum number of saved studies Listing a study does not mean it has been evaluated by the U.
Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details. See Contacts and Locations. Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Have documented functional damage to the central or peripheral nervous system unlikely to improve with present standard of care.
Be at least 6 months post-onset of the disease. If under current medical therapy pharmacologic or surgical treatment for the condition be considered stable on that treatment and unlikely to have reversal of the associated neurologic functional damage as a result of the ongoing pharmacologic or surgical treatment. In the estimation of Dr. Weiss and the neurologists have the potential for improvement with BMSC treatment and be at minimal risk of any potential harm from the procedure.
Be over the age of 18 and capable of providing informed consent. Be medically stable and able to be medically cleared by their primary care physician or a licensed primary care practitioner for the procedure. It could result in an end to insulin injections, and to the disabling and deadly complications of the disease, such as strokes and heart attacks, blindness and kidney disease.
The treatment, which involves making insulin-producing cells from stem cells, was described as a 'phenomenal accomplishment' that will 'leave a dent in the history of diabetes'. Scroll down for video. Scientists yesterday hailed stem-cell research into a cure for diabetes as potentially the biggest medical breakthrough since antibiotics. Harvard University researchers said they had made a 'giant leap forward' in the quest to find a cure for type 1 diabetes. This form affects , Britons, including almost 30, children.
It occurs when the immune system attacks the cells in the pancreas that make the insulin we need to turn the sugar in food into energy. Unable to make any insulin, type 1 diabetics need regular injections to stop blood sugar levels from fluctuating wildly. But the research also offers hope to the three million Britons with type 2 diabetes, in which the body doesn't make insulin or the insulin doesn't work properly.
This version is fuelled by obesity, rather than the immune system and eats up a tenth of the NHS budget. As with many recent medical advances, this one is based on the potential of stem cells, the 'master cells' that can turn into other cell type and are widely seen as a repair kit for the body. A pump administering insulin continuously through catheter can be used as a treatment for diabetes. Harvard researcher Doug Melton, who has two children with diabetes, found a way of making insulin-producing cells.
Dr Melton promised his children he'd find a cure. In some cases the stem cells came from human embryos. But he was also able to turn human skin cells into ones that make insulin — something that would be much more ethically acceptable. Grown in the lab and transplanted into a mouse with diabetes, the cells made insulin and cured the animal, the journal Cell reports.
Importantly, if this is ever to help humans in large numbers, Dr Melton can make billions of cells. The lab-grown cells are just one step away from being trialled in people. Other researchers have made insulin-producing cells but these are the first that seem to work as well as the real thing. Dr Melton, who dedicated his career to finding a cure for type 1 diabetes 23 years ago when his son Sam was diagnosed with the condition, said: People with type 1 diabetes need regular insulin injections to control their blood sugar levels.
It has to be injected because if it were taken as a tablet, it would break down in the stomach and be unable to enter the bloodstream where it acts to reduce the amount of glucose. Either a syringe or an injection pen can be used, with most people needing two to four injections a day.
An alternative to injecting insulin is a portable pump. About the size of a pack of playing cards, the pump is attached to a long, thin piece of tubing, with a needle at the end, which is inserted under the skin.
Most people insert the needle into their stomach. It delivers constant amounts of insulin during the day. If we had shown this was not possible, then I would have had to give up on this whole approach. Now I'm really energised. Dr Melton said he hoped to have human trials under way within a 'few years'. Chris Mason, professor of regenerative medicine at University College London, said it was 'potentially a major medical breakthrough'.
Jose Oberholzer, a diabetes expert at the University of Illinois at Chicago, said the research 'will leave a dent in the history of diabetes', adding: Dr Richard Insel, of the Juvenile Diabetes Research Foundation, which part-funded the research, cautioned that it had so far proved its worth only on mice. The views expressed in the contents above are those of our users and do not necessarily reflect the views of MailOnline. Friday, Sep 14th 5-Day Forecast.
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Stem-cell therapy is the use of stem cells to treat or prevent a disease or condition.. Bone marrow transplant is the most widely used stem-cell therapy, but some therapies derived from umbilical cord blood are also in use. Research is underway to develop various sources for stem cells, as well as to apply stem-cell treatments for neurodegenerative diseases and conditions such as diabetes and.
The information used to compile this Stem Cell Research Timeline comes from many different sources, including the National Institutes of Health.A useful list of links to other stem cell research timelines from around the Web can be found at the bottom of this page.
Today, with the Executive Order I am about to sign, we will bring the change that so many scientists and researchers; doctors and innovators; patients and loved ones have hoped for, and fought for, these past eight years: we will lift the ban on federal funding for promising embryonic stem cell research. Embryonic stem cell research has been in the controversial focus for many years and has gathered a lot of opposition to stem cell research from the public and religious groups. Some believe that there’s a lot of potential in the embryonic stem cell research as only this cell has the flexibility for repairing damaged nerves, organs and tissues, and curing hundreds of deadly diseases.
Stem cells have been shown to repair neurons and regenerate myelin in research studies. Learn how stem cell therapy may provide relief from MS symptoms today. Stem Cell Therapy for Parkinson’s Disease. Today, new treatments and advances in research are giving new hope to people affected by Parkinson’s Disease.